genomic instability leads to the accumulation of many passenger mutations that do not directly impact tumor progression.genomic instability leads to the accumulation of many passenger mutations that do not directly impact tumor progression. a small percentage of the total number of mutations in a cancer cell are driver mutations.a small percentage of the total number of mutations in a cancer cell are driver mutations. driver mutations are those mutations that occur in every type of cancer.driver mutations are those mutations that occur in every type of cancer. lung cancer cells from two different patients could have different driver mutations.lung cancer cells from two different patients could have different driver mutations. a single driver mutation is sufficient for cancer development.a single driver mutation is sufficient for cancer development. a small percentage of the total number of mutations in a cancer cell are passenger mutations.