what role do cfcs play in the catalytic destruction of ozone? what role do cfcs play in the catalytic destruction of ozone? there is no strong scientific evidence that cfcs play a significant role in the catalytic destruction of ozone. ozone is destroyed upon binding to a cfc molecule that has been energized by ultraviolet light. cfc molecules activate chlorine atoms into their catalytic action. cfc molecules migrate to the upper stratosphere where they generate chlorine atoms upon being destroyed by ultraviolet light.