Inherited mutations in BRCA1 or BRCA2 increase the risk of several cancers in addition to breast and ovarian cancer, and inherited breast cancer is associated with younger age of onset compared to non-inherited, sporadic cancer.
Which of the following events in a normal cell from an individual inheriting a mutant allele of BRCA1 or BRCA2 could cause the descendants of that cell to grow into a tumor? (Select all that apply.)
A. Mitotic recombination that results in gene conversion of the mutant allele to the wild-type allele
B. A point mutation in the allele inherited from the normal parent
C. A deletion of the gene copy inherited from the normal parent
D. A deletion of the gene copy inherited from the affected parent
E. Mitotic nondisjunction or loss of the chromosome inherited from the affected parent
F. A second point mutation in the allele inherited from the affected parent