Which of the following statements accurately describe(s) how fructose metabolism in the liver differs from glucose metabolism? Select all that apply
1. In fructose metabolism, the phosphofructokinase reaction is bypassed, and glycolysis can proceed regardless of need.
2. The presence of fructose inhibits the entrance of glucose into glycolysis.
3. The major control point in both glucose and fructose metabolism is the reaction catalyzed by phosphofructokinase.
4. The fructose 1-phosphate pathway can deplete intracellular phosphate/ATP.