During the late 1800s, hundreds of thousands of native-born Americans and immigrants moved west of the Mississippi River into the Great Plains region. This massive movement of people westward sometimes led to conflict with Native Americans (American Indians) who already inhabited this area of the U.S.
*the major reasons that the Natives resisted the movement of newcomers onto the Great Plains;
*the major ways that the Natives resisted the movement of newcomers onto the Great Plains;
*the major reasons that the Natives were unsuccessful in this resistance (that is, the major reasons that the resistance failed).