Which of the following are possible sequences of downstream operations for the recovery and purification of an intracellular product?
1) Cell lysis, centrifugation, filtration, chromatography
2) Filtration, chromatography, centrifugation, cell lysis
3) Centrifugation, chromatography, cell lysis, filtration
4) Chromatography, filtration, cell lysis, centrifugation