A 31-year-old male with HIV presents with headaches and night sweats. He is poorly compliant with his medications. His headaches are severe in the morning but subside throughout the day. He has no other complaints. His last CD-4 count was 95/ mm3. His temperature is 98.9 ° F, blood pressure is 110/ 76 mmHg, and pulse is 88/ min. His physical exam is normal. CT scan of the head shows a ring-enhancing lesion near his right primary motor cortex. What is the best next step in management?
(A) Radiation
(B) Chemotherapy and radiation
(C) Pyrimethamine and sulfadiazine
(D) Stereotactic brain biopsy
(E) Restart highly active antiretroviral therapy (HAART)