ARF GTPases activate Salmonella effector SOPF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy.
a) Explain the role of ARF GTPases in this process.
b) Describe the function of Salmonella effector SOPF.
c) Identify the target of ADP-ribosylation in the host cell.
d) Discuss the significance of inhibiting autophagy in this context.