A young adult female patient was prescribed an appropriate dose of Tylenol #3 during an emergency department visit. Within 48 hours, the patient was brought back to the emergency department by ambulance due to respiratory depression and somnolence. Which of the following is the most likely cause of this response?
1) The patient is HLA-B(*)5701 positive.
2) The patient has CYP2C19(*)2 or (*)3 alleles.
3) The patient is a CYP2D6 ultra-rapid metabolizer.
4) The patient has a deficiency of thiopurine methyltransferase (TPMT).
5) The patient has CYP2C9(*)2 or (*)3 alleles.