One day following extensive debridement of the right leg for a necrotizing soft tissue infection (NSTI), a 40-year-old male remains in the ICU, intubated, and requiring 70 % FIO2. White blood cell count has risen from a preoperative level of 16 × 103/ μL (normal 4.1- 10.9 × 103/ μL) to 34 × 103/ μL. Serum lactate has also risen. Which of the following is the best next step in treatment?

(A) Second-look operation

(B) Amputation of the right leg

(C) Broaden antibiotic coverage

(D) CT scan of the leg

(E) Start pressors