Following an IV bolus dosing of an experimental drug X (EDX), the following concentrations are found. Assume that the drug follows the One Compartment Open Model. What is the overall elimination rate constant? What is the unit of the rate constant?
Time (hour) 0.25 0.5 1 3 6 12 18
Concentration (mcg/ml) 8.21 7.87 7.23 5.15 3.09 1.11 0.4