A patient wishes to be vaccinated against Dengue virus before traveling overseas to an endemic region. The doctor tests the patient's serum for prior exposure, the results of which are summarized below. If the patient were to be infected with another serotype of DENV, which serotype would most likely lead to development of DHF/DSS in this person?
DENV1 - does binding, does neutralizing
DENV2 - does binding, does not neutralize
DENV3 - does binding, does neutralizing
DENV4 - does not bind, does not neutralize
a) DENV3
b) DENV2
c) DENV4
d) Infection with all of these would likely induce DHF/DSS in the patient
e) DENV1