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The Answer: 1528 was the year the Inca Wayna Capac died from smallpox

The Inca Wayna Capac died of smallpox in 1528.

Wayna Capac ruled the Inca Empire between 1493 and 1525 after inheriting it from his father Tupac Yupanqui. He led the empire to its maximum extension, conquering territories near Cajamarca and Quito. The Incas arrived from Pasto (Colombia) to the Maule River (Chile). While in charge, the Incas lived a period of peace.

Wayna Capac died in Quito for smallpox, a disease that came from Europe with the Spanish expeditions to the New World, in 1528. He did not definitely name a successor. To his death followed a Civil War between his sons Huascar and Atahualpa, which meant the decadence of the Incas and the subsequent conquest by Francisco Pizarro.