The biosynthesis of fatty acids and lipids meets two imperatives in the
cell :
- supply of fatty acids necessary for the synthesis of structural lipids;
- storage of energy.
The synthesis of fatty acids goes through a dehydration step during its synthesis. and its catabolism goes through a hydration stage, which shows the importance of H2O molecules to build lipids (even cholesterol).
Synthesis of the fatty acid:
firstly, acetyl-ACP and malonyl-ACP were condensed, followed by reduction of acetoacetyl-ACP to β-hydroxybutyryl-ACP, followed by dehydration of β-hydroxyacyl-ACP, and finally reduction of the double bond by NADPH + H
Catabolism:
The reverse steps will occur: a beta oxidation, a hydration of the molecule, and finally another oxidation.