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Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A: duplication
B: Insertion
C.Inversion
D. substitution
E.translocation

Respuesta :

Answer:

E.translocation

Explanation:

The chromosomal disorder CML is caused by reciprocal translocation between chromosome 9 and chromosome 22, in which rearrangement of chromosomes takes place.

Due to this rearrangement, part of chromosome 9 having ABL1 gene gets fused with part of chromosome 22 having BCR gene and resulting chromosome is known as Philadelphia chromosome.

ABL1-BCR fusion gene represents an oncogene that codes for a mutated protein that leads to unregulated cell division and impaired DNA binding and can cause cancer.

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