The correct answer to this open question is the following.
The factor that played a major role in the Mughal Empire's rise to power in the 16th century was the advantage they had in using gunpowder.
Approximately in 1526, the city of Delhi was captured by Babur, and this represented the beginning of the Mughal Empire years. Babur first had to defeat the King of Delhi, Ibrahim Lodi is the famous Battle of Panipat were many lives were lost. The Mughal army used gunpowder in their weapons and this represented a major advantage to win the war.
