Step 1. Use Multiplication Distributive Property
2^2x^2y^2 * -3x^2 * 4y^4
Step 2. Simplify 2^2 to 4
4x^2y^2 * -3x^2 * 4y^4
Step 3. Take out the constants
(4 * -3 * 4)x^2x^2y^2y^4
Step 4. Simplify 4 * -3 * 4 to -48
-48x^2x^2y^2y^4
Step 5. Use product rule: x^a x^b = x^a + b
-48x^2 + 2 y^2 + 4
Step 6. Simplify 2 + 2 to 4
-48x^4y^2 + 4
Step 7. Simplify 2 + 4 to 6
-48x^4y^6
