Kisspeptin is a protein in humans that has an important role in initiating secretion of the releasing factor gonadotropin-releasing hormone (GnRH). Endocrinologists are finding that the protein kisspeptin and its receptor are central to sexual maturation at puberty. Neurons that release kisspeptin carry estrogen receptors. If this is a negative feedback system, high levels of estrogen would be expected to: decrease kisspeptin synthesis. increase kisspeptin synthesis. neither increase nor decrease kisspeptin synthesis because steroid hormones do not affect protein synthesis.

Kisspeptin is a protein involved in the regulation of gonadotropin-releasing hormone (GnRH): it stimulates the secretion of GnRH. GnRH than stimulate the release of gonadotropins such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland. FSH stimulates the production of estrogens by the granulosa cells of the ovarian follicles.

In negative feedback system, high levels of estrogen will bind to their receptors on neurons that release kisspeptin and inhibit its further release.