Answer:
When the cell becomes too large, the DNA cannot keep up with demands.
Explanation:
What is DNA Overload :
As the cell grows, the demands are placed on the cell's DNA. If this ratio gets too low, the cell cannot efficiently move materials in & out of the cytoplasm. This process is called DNA overload.
THE CELL CYCLE
Cell cycle is a series of cellular events during which the cell grows, prepares for division & then divides.
Cell Growth and Division
When the cell becomes large, DNA and the more trouble the cell has moving enough nutrients and wastes across the cell membrane.