Answer:
You would expect to find glutamic acid on the fringes of the three-dimensional protein structure while valine would be found mostly inside the protein structure.
This is because hydrophilic molecules are ‘water-loving’ because they carry a charge and can, therefore, interact ‘positively’ with water by forming hydrogen bonds with the polar water molecules. Hydrophobic molecules on the other hand are water-hating. They carry no charge hence have no way of ‘positively’ interacting with the polar water molecules.
Remember the structure of the cell membrane too? The negatively-charged phosphate ends of the phospholipid bi-layer sandwich the non-polar fatty acid chains because they don't ‘like’ interacting with water. This applies to the same principle.
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