Answer:
DNA replication always occurs in the nucleus.
Explanation:
Prokaryotes lack the membrane-bound organelles. The nucleus is a double membrane-bound organelle and is absent in prokaryotic cells. The DNA of prokaryotes is present in the cytoplasm itself. Therefore, DNA replication in prokaryotes does not occur in the nucleus.
On the other hand, the DNA of eukaryotes is present in a well-defined nucleus. DNA replication in eukaryotes occurs in the nucleus; not in the cytoplasm. For example, DNA replication in humans occurs in the nucleus but the process takes place in the cytoplasm of a bacterial cell.