Pyruvate is decarboxylated and oxidized to acetyl CoA, and NAD+ is reduced to NADH.
This process occurs in aerobic respiration whereby the products of glycolysis (anaerobic) in the cytoplasm become the substrate for the citric acid cycle in the mitochondria. The citric acid cycle cannot occur in the absence of oxygen, In the absence of oxygen, the pyruvate of converted to lactic acid which is broken down and excreted by the cell.
Explanation:
Pyruvate is a 3-carbon molecule product of glycolysis. In the presence of oxygen in the cell, the pyruvate is decarboxylated (One C- is removed through the mediation of pyruvate dehydrogenase complex) – including two oxygens- to form carbon dioxide. A redox reaction also occurs in the process a Coenzyme A is joined to form acetyl-CoA and an NAD+ reduced to NADH.
Learn More:
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