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A mutation is found that prevents transcription of the HOX3A gene, which is known to be on chromosome 12. Genetic mapping of the mutation suggests that it is located on chromosome 11. Which of the following could make these two observations possible? (Select all that apply.)
a) The mutation affects a transcription factor that binds to HOX3A gene sequences.
b) The mutation changes the DNA sequence of an enhancer of the HOX3A gene.
c) The mutation prevents ribosome binding by altering sequences of the HOX3A mRNA.
d) The mutation increases transcription of an miRNA that has sequence homology to the HOX3A gene.

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manuelitasotelo

Answer:

a) The mutation affects a transcription factor that binds to HOX3A gene sequences.

Explanation:

The mutation can affect a transciption factor that promotes HOX3A transcription. For example, if the mutation causes the transcription factor not to be synthesized, there will be no signal required to initiate HOX3A transcription. On the other hand, if the mutation generates changes in the form of the transcription factor, it may not be recognized in the promoter region of the HOX3A gene.

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