By what mechanism does PI-3 phosphate promote activation of protein kinase B (PKB)?
a. recruiting PKB to the plasma membrane
b. recruiting the activating kinase PDK1 to the plasma membrane
c. releasing inhibition of the catalytic site by the PH domain
d. the first and second answers are correct
e. all of the above
The mechanisms are: recruiting PKB to the plasma membrane, recruiting the activating kinase PDK1 to the plasma membrane
, and releasing inhibition of the catalytic site by the PH domain.
