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If homeostasis fails, the organism could become dysfunctional, develop illnesses due to vulnerability to various microbes and/or die, simply. Homeostasis is the act where the organism strives to balance out its internal disposition. This mechanism helps the organism survive through various environmental changes. 
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If homeostasis fails, the organism will become a disaster in a sense, and it can result in heatstroke and/or hypothermia. Failing to keep your energy balance can result in becoming overweight or developing type 2 diabetes. Hope this helps you out!

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