Answer:
Explanation:
Viruses in the host body are constantly changing and mutating in the dynamics of the physical and functional forms. For each kind of mutation the host body develops new antibodies.
Some viruses mutate too quickly and they are not detected by the antibodies in the host for their destruction. This can be considered as limitation of ELISA. ELISA is enzyme linked immunosorbent assay. It is a plate based assay technique used for the purpose of quantification of antibodies.
The number of antibodies produce will be related to the number of viral cells present in the body of the host.
Some viruses cannot be targeted by antibodies for destruction because they have a long incubation time, being endoparasitic. This is a limitation to develop an ELISA-based protocol to detect these diseases.
The basic principle of the ELISA reaction is the immobilization of one of the reagents on a solid phase, while another reagent can be bound to an enzyme, preserving both the enzymatic and immunological activity of the antibody.
With this information, we can conclude that some viruses cannot be targeted by antibodies for destruction because they have a long incubation time, being endoparasitic. This is a limitation to develop an ELISA-based protocol to detect these diseases.
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