The dosage of a certain drug is reduced when administered to a pregnant woman with liver impairment. What is the other clinical situation that requires reduction in the dose of the drug during pregnancy?

Defective renal function could result in a high amount of drug levels. It might also increase the drug disclosure to the tissues and lead to a high level of drug distribution to the fetus. Epilepsy, diabetes, and hypertension do not have a straight effect on drug metabolism and excretion. However, they have ancillary impact in later phases when liver and kidneys are affected secondarily.

osondumartins osondumartins · Answer 2 · 2020-02-06T05:46:37+01:00

Answer: RENAL IMPAIRMENTS

Explanation: RENAL IMPAIRMENTS is a term used to describe the inability of the Renal System (Kidneys) to effectively carry out it's activities. When a pregnant woman has Renal impairments,it is Generally expected that the level or amount of drugs dose issues to her be reduced to a manageable quantity.

The kidneys are directly responsible for the FILTRATION of the urines and Blood,so if high quantity of drugs are present it might not be able to effectively perform it tasks. Epilepsy, Hypertension and diabetes have late stage renal impairments.