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Acetylcholinesterase (AChE) is a protein that catalyzes the conversion of acetylcholine to acetate and choline. When the concentration of AChE in an aqueous solution is held constant, the rate of the reaction catalyzed by AChE increases with increasing concentrations of substrate. At low concentrations of acetylcholine, a small increase in the substrate concentration results in a large increase in the reaction rate. At high concentrations of acetylcholine, however, a large increase in the substrate concentration results in only a small increase in the reaction rate.
Which of the following statements correctly explains the observed effect of the acetylcholine concentration on the rate of the enzyme-catalyzed reaction?

A.The active site of AChE is specific for acetylcholine, and only one substrate molecule can occupy the active site at a time.
B. AChE begins converting product into substrate as the acetylcholine concentration changes from low to high.
C. The AChE protein becomes denatured as the acetylcholine concentration changes from low to high.
D. The substrate specificity of AChE changes as the acetylcholine concentration changes from low to high

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Answer:

The answer is A.The active site of AChE is specific for acetylcholine, and only one substrate molecule can occupy the active site at a time.

Explanation:

  • Accetylcholineesterase (AChE) is a hydrolytic enzymes that hydrolyses the neurotransmitter acetylcholine into acetate and choline.
  • AChE works at the synaptic connections, facilitating the transmission of nerve impulses by breaking down acetylcholine.

Effect of Substrate on Acetylcholineesterase Activity:

  • At constant enzyme concentration, an increase in the substrate increases enzyme activity.
  • At low substrate concentration, the enzyme activity also increases.
  • At very high substrate concentration, the rate of catalysis increases up to a certain point after which in increase in rate is observed. This occurs because all the enzyme molecules are saturated with the substrate.
  • Therefore, since, the enzyme can house only one substrate molecule at a time, the rate of catalysis becomes constant and does not rise.

luisvaschetto

The statement 'the active site of AChE is specific for acetylcholine, and only one substrate can occupy the active site at a time' explains the effect of the acetylcholine on the rate of the reaction (Option A).

  • Acetylcholine (ACh) is a neurotransmitter required for the normal functioning of the parasympathetic nervous system (PNS).

  • Moreover, Acetylcholinesterase (AChE) is an enzyme that catalyzes the breaking down of ACh into acetic acid and choline.

  • AChE binds specifically to ACh at the enzyme's active site in order to hydrolyze it into acetic acid and choline.

  • The relationship between enzyme activity is often directly proportional to the concentration of substrate, which is a consequence of the specificity of the binding of the enzyme by its corresponding substrate.

In conclusion, the statement 'the active site of AChE is specific for acetylcholine, and only one substrate can occupy the active site at a time' explains the effect of the acetylcholine on the rate of the reaction (Option A).

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https://brainly.com/question/6651475

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