Enzymes are ____________ whose three-dimensional shape is dependent upon environmental variables, including temperature. Enzymes function most efficiently at ____________ temperatures. Temperature increases caused by fever result in ____________ efficient enzyme activity and enzymes are able to make ____________ product in a given period of time. This occurs because increased ____________ energy of molecules enhances substrate and enzyme contact. Severe increases in temperature ____________ the bonds that hold an enzyme's shape. The enzyme subsequently ____________ , permanently ____________ function. The ____________ the temperature, the more likely this is to occur.