The drug propanolol, which is used as an anxiolytic (relieves anxiety) has a half-life of 3.9 h. How long does it take for 80% of a dose of propanolol to be eliminated?

Respuesta :

Answer:

After 9.0 hours

Explanation:

Using the decay equation, we can write the amount of drug propanol after time t as:

[tex]m(t)=m_0 e^{-\lambda t}[/tex] (1)

where

m(t) is the mass left at time t

[tex]m_0[/tex] is the initial mass of the substance

[tex]\lambda[/tex] is the decay constant

t is the time

The decay constant is related to the half-life of the substance as follows:

[tex]\lambda=\frac{ln2}{t_{1/2}}[/tex]

where [tex]t_{1/2}[/tex] is the half-life.

Here we have

[tex]t_{1/2}=3.9 h[/tex]

So the decay constant is

[tex]\lambda=\frac{ln 2}{3.9}=0.178 h^{-1}[/tex]

We want to find the time t after which the dose is 80% of the initial dose is eliminated, so the time t after which 20% of drug is left, so

[tex]\frac{m(t)}{m_0}=0.20[/tex]

Substituting eq(1) and solving for t, we find:

[tex]t=-\frac{ln(\frac{m(t)}{m_0})}{\lambda}=-\frac{ln(0.20)}{0.178}=9.0 h[/tex]