Respuesta :

Answer:

A polyadenylation signal or poly(A)

Explanation:

Termination. In eukaryotes, transcription is terminated differently for the all 3 different RNA polymerases. Transcription is terminated by two elements: i) a poly(A) signal and ii) a downstream terminator sequence.

In eukaryotic protein-encoding genes, the cleavage site in the RNA occurs between an upstream( the sequence before the cleavage site) AAUAAA  and a downstream GU-rich, separated by approx 40-60 nucleotides. After they both have been transcribed, a protein knows as CPSF  and another protein called CstF( in humans)  helps in termination.

luisvaschetto

The polyadenylation signal or poly (A) is responsible for the termination of transcription in eukaryotic protein-coding genes.

  • Eukaryotic transcription occurs in three sequential steps, i.e., initiation, elongation, and termination.

  • The poly-Adenine (A) tail is a long chain of Adenine nucleotides, which is added to eukaryotic messenger RNAs (mRNAs).

  • The poly A tail is added to the 3′ end of the precursor mRNA (pre-mRNA) once the elongation step is complete.

  • This sequence (poly A) protects the mRNA from the degradation caused by nuclease enzymes.

In conclusion, the polyadenylation signal or poly (A) is responsible for the termination of transcription in eukaryotic protein-coding genes.

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