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Answer:

They are altered by the many changes that happen during a womans bodying during pregnancy, which can change the distribution, adsorption, metabolism and excretion of drugs, therefore impacting their pharmacodynamic properties during pregnancy.

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Explanation:
Increased plasma volume increases the volume of distribution for water-soluble drugs, and, therefore, pregnancy may be associated with lower peak and steady-state drug concentrations if the dosing is unchanged. Albumin concentration decreases during the second trimester and declines further throughout pregnancy

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