Answer
Variable regions of a heavy chain and light chain combined
Explanation:
An epitope refers to or can be explained as the specific target against which an individual antibody binds. It can further be described as the part of the antigen that binds to a specific antigen receptor on the surface of a B cell.
It should be understood that, an epitope is capable of stimulating an immune response. And, it can be used in proteomics and the study of other gene products.
Finally, on the antigen or antibody, an epitope is known to associate with variable regions of a heavy chain and light chain combined.
An epitope is associated with the variable region of heavy and light chain combined.
It is also called antigenic determinant, and is the part of the antigen, which is recognized by the immune system, mainly by the antibodies. It is the specific piece of an antigen to which binding of antibody takes place. The component of antibody, which combines with an epitope is known as paratope.
The recognition of epitope takes place by the paratope of an antibody. More will be the epitopic density lesser will be the recognition by the immune cell and higher will be the probability of the occurrence of disease. Therefore, epitope is associated with variable region of both heavy and light chain of the antibody.
Thus, an epitope is associated with the variable region of heavy and light chain of the antibody.
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