Inhibitors of the electron transport chain exert their effects through a variety of mechanisms. _ blocks electron transport and proton pumping via inhibition of Complex IV. blocks electron transport and proton pumping via inhibition of Complex I. blocks electron transport and ATP synthesis by inhibiting the exchange of ATP and ADP across the inner mitochondrial membrane. __blocks ATP synthesis without inhibiting electron transport by dissipating the proton gradient

Inhibitors of the electron transport chain exert their effects through a variety of mechanisms. AZIDE______ blocks electron transport and proton pumping via inhibition of Complex IV. _ROTENONE_______blocks electron transport and proton pumping via inhibition of Complex I. _ATRACTYLOSIDE_______blocks electron transport and ATP synthesis by inhibiting the exchange of ATP and ADP across the inner mitochondrial membrane. _DNP_______blocks ATP synthesis without inhibiting electron transport by dissipating the proton gradient

luisvaschetto luisvaschetto · Answer 2 · 2021-11-30T20:22:02+01:00

AZIDE inhibits Complex IV, ROTENONE inhibits Complex I, ATRACTYLOSIDE inhibits the exchange of ATP and ADP, while DNP blocks ATP synthesis.

Cellular respiration has three stages: glycolysis, the Krebs cycle and oxidative phosphorylation.

During oxidative phosphorylation, the electron transport chain is coupled to the generation of an electrochemical proton gradient across the inner mitochondrial membrane, which is subsequently used to generate ATP.

Azide inhibits cellular (mitochondrial) respiration by blocking cytochrome c oxidase (also known as Complex IV), which is a key carrier of electrons in oxidative phosphorylation.

Rotenone blocks the electron transport chain by inhibiting the enzyme NADH ubiquinone reductase (also known as mitochondrial complex I), thereby preventing the availability of oxygen for cellular respiration.

Atractyloside (ATR) is a natural, toxic glycoside that blocks the synthesis of ATP by inhibiting the exchange of ATP in the mitochondria with ADP in the cytosol.

2,4-Dinitrophenol (DNP) is an organic compound that allows protons (H+) to pass across the inner mitochondrial membrane, thereby bypassing ATP synthase.

In conclusion, AZIDE inhibits Complex IV, ROTENONE inhibits Complex I, ATRACTYLOSIDE inhibits the exchange of ATP and ADP, while DNP blocks ATP synthesis.

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