De novo nucleotide synthesis differs for purine and pyrimidine bases. However, some molecules are important precursors and intermediates in both pathways. Which intermediates are common to both purine and pyrimidine nucleotide synthesis? orotate formate glycine aspartate PRPP Purine bases, which have two rings, have a more complex synthetic pathway than do pyrimidine bases, which have one ring. As a result, purine synthesis requires more components than pyrimidine synthesis. Which amino acids contribute atoms to the purine structure in de novo purine synthesis? lysine aspartate glycine glutamine histidine

Aspartate is a precursor in both the synthesis of purine and pyrimidine. It aids in the formation of Carbamoyl Aspartate in pyrimidine synthesis while in purine, it contributes nitrogen 1 to the purine ring. PRPP is needed in the activation of ribose sugar in the purine nucleotide synthesis, while in that of pyrimidine, it aids in the conversion of orotate to OMP by adding phosphate group to orotate.

Aspartate, glycine and glutamine are precursors in the de novo synthesis of purine nucleotides. Aspartate contribts nitrogen 1, glycine cotributes C4, C5 and nitrogen 7 while glutamine contributes N3 and N9.

aliasger2709 aliasger2709 · Answer 2 · 2021-12-31T16:08:38+01:00

The process of formation of complex molecules from sugar and amino acids (complex molecules ) is called De nova synthesis.

1. The common intermediate in both purine and pyrimidine synthesis is :

Option D. Aspartate

Option E. PRPP

Aspartate acts as a precursor in both purine and pyrimidine nitrogenous base formation. It forms carbamoyl aspartate during pyrimidine synthesis while it contributes one nitrogen to the purine ring during purine synthesis.

Phosphoribosyl pyrophosphate (PRPP) activates the ribose sugar in purine synthesis and converts orotate to OMP by adding phosphate during the pyrimidine synthesis.

2. The amino acid that contributes atoms to purine is:

Option B. Aspartate

Option C. Glycine

Option D. Glutamine

All the above-stated amino acids are a precursor in the purine synthesis by the de nova process.

N1 is provided by aspartate, N7, C4 and C5 are contributed by glycine and N3 and N9 by glutamine amino acid.

Therefore correct options are 1. D and E, 2. B, C and D.

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