Figure 1. Receptor proteins produced as a result of alternative splicing followed by activation of a second messenger
Cell signaling in eukaryotes is often dependent on receptor proteins located in the plasma membrane. During the production of the mature mRNA molecules coding for these receptors, pre-mRNA molecules are processed to remove introns and to connect exons together. The exons contain the sequences that code for proteins. In certain instances, different mature mRNA molecules can be formed from the same pre-mRNA by alternative splicing, which results in different protein sequences in the resulting polypeptides. Figure 1 represents the expression of a gene with 5 exons that can be alternatively spliced to produce receptor protein A and receptor protein B.

Explain how ligand A and ligand B can cause identical cellular responses in a cell.

Ligand A and ligand B can cause identical cellular responses in a cell due to the fact that there are cross-linkages in the various enzymatic activities taking place in the receptor proteins located in the plasma membrane.

This implies that a particular compound in the cell signaling in eukayortes can be triggered by some mechanism. For example as we can see right in the diagram; The ligands can trigger the G-protein in the plasma membrane which result into increase in cAMP.

In addition to that; IP3/DAG pathway can signal and trigger the calcium influx moving into the cytoplasm from the endoplasmic reticulum

mahima6824soni mahima6824soni · Answer 2 · 2022-01-11T14:54:55+01:00

Cellular response is a process in which behavior of a cell changes due to chemical changes within the cell and the ligands are the binding molecule which help in cellular response.

What are Ligands?

A ligand is an ion or molecule that binds to a receptor, which is a receiving molecule. When a ligand attaches to its receptor, the shape or activity of the ligand Is changed, resulting in a variety of cellular response.

What is Cellular response?

when various molecules bind together, they attach to the corresponding receptors they induce changes in the behavior of the cell. This is called as Cellular response.

In the given question Ligand A and Ligand B are causing the identical cellular response In the cell due to:

Due to cross-linkages in the numerous enzymatic activities taking place in the receptor proteins situated in the plasma membrane, ligand A and ligand B might produce identical physiological responses in a cell.

This means that a specific molecule in eucaryotic cell signaling can be induced by a process.

Ligands can activate the G-protein In the plasma membrane, causing a rise in cAMP.

Furthermore, the IP3/DAG route can signal and stimulate calcium influx from the endoplasmic reticulum into the cytoplasm.

Chemical signals connect to their appropriate receptors, causing actions within the cell that modify the cell's behaviour.

Thus, the Ligand A and ligand B can cause identical cellular responses in a cell.

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