1. John is suffering from autosomal dominant deafness (D) and his wife Mary is normal.
Considering complete penetrance for this trait (P=1), what is the probability that this
couple's first child would have this disorder?

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06mae

Answer:

Autosomal dominant inheritance: A person affected by an autosomal dominant disorder has a 50 percent chance of passing the mutated gene to each child. The chance that a child will not inherit the mutated gene is also 50 percent. However, in some cases an autosomal dominant disorder results from a new mutation that occurs during the formation of egg or sperm cells or early in embryonic development. In these cases, the child's parents are unaffected, but the child may pass on the condition to his or her own children.