The Proclamation of 1763 was created by King George III and was made after the French and Indian War. Great Britain had gained territory after this war that had belonged to the French.
After Great Britain had gained new territory, they wanted to make sure the colonists knew where they stood and that they could not expand westward. This angered the colonists, as they wanted to keep expanding. They heavily objected to the Proclamation of 1763 and felt as if Great Britain should not get a say in what they do, as they themselves were the ones settling there.
While a lot of things that Great Britain did angered the colonists, this was just one of the occurrences that lead to the American Revolution.