The correct answer to this open question is the following.
My top five list of European colonization's most impactful changes on Native Americans is the following.
1) The constant removal of the Native American Indian tribes from their native lands. Native American Indians were constantly relocated to other lands.
2) European diseases. Europeans brought many diseases that affected and in some cases wiped out 80 percent of Native American Tribes. We are talking about diseases such as influenza, smallpox, chickenpox, measles, and cholera.
3) The introduction of horses. Horses were unknown in the Americas. European colonizers brought horses with them and really changed the way Native Indians lived.
4) The introduction of metal utensils, tools, and copper kettles.
5) The evangelization process. Some European colonizers, particularly the Spaniards were also interested in evangelization in the Catholic religion.
