Answer:
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Explanation:
The innate immune response is the first mechanism for host defense found in all multicellular organisms. The innate immune system is more ancient than the acquired or adaptive immune response, and it has developed and evolved to protect the host from the surrounding environment in which a variety of toxins and infectious agents including bacteria, fungi, viruses and parasites are found (1).
The immune system is complex and is divided in two categories: i) the innate or nonspecific immunity, which consists of the activation and participation of preexistent mechanisms including the natural barriers (skin and mucosa) and secretions; and ii) the adaptive or specific immunity, which is targeted against a previously recognized specific microorganism or antigen. Thus, when a given pathogen is new to the host, it is initially recognized by the innate immune system and then the adaptive immune response is activated (2). Innate immunity is the host’s first line of defense and is intended to prevent infection and attack the invading pathogens.This nonspecific mechanism is fast (minutes to hours) while the adaptive response takes longer (days to weeks).
Innate immunity is comprised of different components including physical barriers (tight junctions in the skin, epithelial and mucous membrane surfaces, mucus itself); anatomical barriers; epithelial and phagocytic cell enzymes (i.e., lysozyme), phagocytes (i.e., neutrophils, monocytes, macrophages), inflammation-related serum proteins (e.g., complement, C-reactive protein, lectins such as mannose-binding lectin, and ficolins); surface and phagocyte granule antimicrobial peptides (e.g., defensins, cathelicidin, etc.); cell receptors that sense microorganisms and signal a defensive response (e.g., Toll-like receptors); and cells that release cytokines and inflammatory mediators (i.e., macrophages, mast cells, natural-killer cells). Once the interaction host-invader pathogen enters, a signaling cascade is initiated which enhances the immune response and activates specific mechanisms (3-5). This natural immune response is designed to: a) prevent infection, b) eliminate invader pathogens, and c) stimulate the acquired immune response.
The correct examples of physical, chemical, and biological barriers are coughing, saliva, and complement system respectively.
Barriers may be defined as something that blocks the free passage of any object, compound, or thing.
Coughing mediates the physical barrier that kills the pathogen and improves the body's immune system at the physical level. Saliva consists of an enzyme that kills the pathogens on body surfaces, so it is classified under a chemical barrier. Biological barriers involve the action of the complement system which performs the activity of lysis of pathogen particle and stimulate the body's immune response.
Therefore, the correct examples of physical, chemical, and biological barriers are coughing, saliva, and complement system respectively.
To learn more about Biological barriers, refer to the link:
https://brainly.com/question/24881456
