Answer:
Europeans weren't traveling to the Americas at that point. No exposure to infected Europeans means that the American population was safe from the plague.
Explanation:
The reason the Americas were safe from the widespread loss of life initiated by the plague was that the Europeans had not started travelling to the Americas yet
A relevant timeline to explain is:
There was more than a hundred year gap between the Europeans going to the Americas and the period they were affected by the plague which is why the Americas were safe from it.
In conclusion, Americas were safe from the plague because of lack of European contact.
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