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Make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Provide reasoning to support your claims based on the position of the PDC -catalyzed reaction in the sequence of the cellular respiration pathway.

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Answer:

Glycolysis: No change - glycolysis continues PFC is not needed, glycolysis occurs before conversation of pyruvate to acetyl - CoA

Krebs Cycle: Decrease - krebs cycle greatly slowed / deceased if there isn't acetyl - CoA; Occurs after conversation of pyruvate to acetyl - CoA

Explanation:

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PDC deficiency directly regulates the concentration of NADH produced during glycolysis and Krebs cycle as it affects the concentration of acetyl CoA that also participate in the two vital processes.

  • Krebs cycle occurs in the mitochondrial matrix. This process derives energy from metabolic substrates like carbohydrates, fatty acids, and amino acids.
  • Malfunctioning of the Krebs cycle deprives energy from the body.
  • Moreover, in PDC deficiency oriented Krebs cycle the carbohydrate substrate after the breakdown does not get converted into acetyl CoA.
  • This leads to the increase in build up of the lactate and alanine.
  • Lack of energy production during Krebs and glycolysis cycles result in symptoms of lethargy, stress, higher intake of carbohydrates, and tachypnea.

Learn more about Krebs cycle:

https://brainly.com/question/13153590

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