Which of the following outcomes will most likely result from the irreversible binding of GDP to the G protein?

The intracellular concentration of glycogen will increase as the result of the irreversible binding of GDP to the G protein due to the not respond to the binding of norepinephrine to the beta-adrenergic receptor which prevents the separation of the G protein alpha subunit.

This leads to the activation of adenylyl cyclase. PKA will be lesser and glucose 1 phosphate as the dissociation of G protein will not take place and ultimately to glycogen accumulation.

ajeigbeibraheem ajeigbeibraheem · Answer 2 · 2022-01-03T13:18:24+01:00

The most likely result from the irreversible binding of GDP to the G protein results in an increase in intracellular concentration of glycogen.

G proteins are a group of proteins that operate as signaling molecules inside cells, conveying signals from various external stimuli to the cell's core. They govern their signaling cycle with the help of GDP.

In an irreversible binding of GDP to the G protein, the G protein is rendered inactive.
The GDP is swapped by GTP to initiate the protein, and the G protein then sends out its signal.

This results in an increase in the intracellular concentration of glycogen because of the non-response to norepinephrine binding and to the beta-adrenergic receptor, which inhibits the G protein alpha subunit from being separated.

Learn more about G proteins here:

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