Introduction. CFTR gene, which is responsible for this disorder, contains 27 exons spreading over 250 kb of chromosome 7 (7q31) and encodes an mRNA of 6.5 kb.
Construction and placement of the CFTR protein in the cell membrane occurs in distinct phases. Located on the long (q) arm of chromosome 7 at position 31.2, the CFTR gene is comprised of 27 exons that encode its genetic sequence (1). An exon is a portion of a DNA that contains the code for a protein structure.
