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I think the correct answer from the choices listed above is the second option. Compared with Medieval art, a major theme in Renaissance art was religion.  Humanism and the Renaissance played a direct role in sparking the Reformation, as well as in many other contemporaneous religious debates and conflicts. Hope this helps.

Compared with Medieval art, a major theme in Renaissance art was religion. Option A. This is further explained below.

What is Renaissance?

Generally, the 14th–16th centuries' classical models–influenced the rebirth of European art and literature.

In conclusion, A primary topic of Renaissance art, in contrast to Medieval art, was religion.

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