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The best and most correct answers among the choices provided by your question is the first and the last choice.

Both the southern plantations and the Middle colonies are the American settlements that enjoyed profitable farming.

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Answer:

Southern plantations.

The Middle Colonies.

Explanation:

Both the Southern plantations and the Middle colonies enjoyed very profitable farming. The Southern plantations mostly dealt with cash crops, such as cotton, indigo, coffee and sugar cane. These crops were usually farmed by slaves. In the case of the Middle Colonies, the crops consisted of wheat and other grains, with a great abundance of fertile soil.