Answer:
The answer to the given question is =7/8
Explanation:
In autosomal dominant traits, one copy of the affected gene is enough to cause the disease. Let ’A’ be the affected gene, ‘a’ be the non affected gene. Since IV-4’s parents are a couple of affected and non-affected. So, he has the genes Aa, i.e. a single affected gene.
A a
a aA aa
a aA aa
Number of children affected=[tex]\frac{1}{2}[/tex]
Number child affected out of three = [tex](\frac {1}{2}) ^{3}[/tex]
At least one child affected out of three = 1-P (number of children affected out of 3 )
= [tex]1-(1/2)^{3}[/tex]
= [tex]\frac{7}{8}[/tex]
So, the answer to the given question is 7/8
