Red blood cells usually live for about 120 days before they die and need to be replaced. Sickle cells are fragile — their membranes break apart easily, causing the cells to die after only 10 to 20 days. The result in those with sickle-cell disease is a chronic shortage of red blood cells known as anemia.
Based on this information, why do people with anemia become easily fatigued?
When people have anemia, their body doesn't produce enough red blood cells. They don't get enough oxygen, which makes them feel fatigued and can also cause serious health complications.