When a tautomeric shift occurs, then the resulting mutation ALWAYS changes a purine to a purine or a pyrimidine to a pyrimidine. A tautomeric shift may lead to a point mutation.
A mutation is any alteration in the nucleotide (DNA) sequence of the genome of an individual.
A tautomeric shift can be defined as a temporary change in the nucleotide base structure.
A transition mutation is a point mutation of one purine or pyrimidine base pair to the other purine/pyrimidine that occurs when one nucleotide base undergoes a tautomeric shift during DNA replication.
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