In a DNA profile, bands should be compared to establish paternity. 1) Alleged father number 1 could be excluded. 2) Alleged father number two may be the father. 3) No, more markers and repetitions are needed.
What is a genetic profile?
- The genetic profile is the series of alleles characteristic of each individual concerning a series of DNA fragments.
- Once genetic profiles are obtained by using PCR/electrophoresis, they must be subjected to interpretation.
- The researcher must compare profiles to find concordance between individuals or the lack of it.
How to improve the study?
- Using several markers in the study increases the matches chances.
- There must be a repetition of the study.
In the exposed example, we have a profile of the mother, the child, and two potential fathers.
We need to find out which of the two men might be the father.
How to interprete the results from the pattern of bands?
- We need to compare the child's pattern of bands with the mother's ones and each of the potential fathers.
- We need to look for the child's lanes that match the most with each of the potential fathers' lanes and discard those that differ the most.
- These patterns that differ the most can be excluded.
- Individuals suspected to be related must be subducted to a repetition of the study.
- As the statement says, any band that does not matches the mother's side comes from the father's side.
Comparison
- Mother-Child ⇒ In these profiles, the child only matches one band with the mother. You will find this match as a red circle in the image in the attached files.
- 1st profile ⇒ In this profile, the child does not match with any of the bands of the first alleged father.
- 2nd profile ⇒ In this profile, the child matches with only one of the bands of the second alleged father. You will find this match as a green circle in the image in attached files.
1. Can either man be excluded as the father? Explain.
Yes. Concerning only the analyzed markers, we could say that alleged father number one can be excluded since there is no bands' matching. This man is the one that differs the most.
2. Which man may be the father of the child? Explain.
Since one of the bands match, the alleged father number two may be the child's father.
3. Is this DNA profile sufficient to establish paternity? Why or why not?
A deeper study should be done to establish paternity, which includes more markers and more repetitions. There should be more than only one matching band.
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